从伊朗两所教学医院的临床样本中分离出的高毒力肺炎克雷伯菌的形态。
The face of hypervirulent Klebsiella pneumoniae isolated from clinical samples of two Iranian teaching hospitals.
机构信息
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Division of Bacteriology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Ann Clin Microbiol Antimicrob. 2021 Aug 31;20(1):58. doi: 10.1186/s12941-021-00467-2.
Abstract
Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a pathogen of global concern. In this study, both phenotypic and genotypic tests were used to detect hvKp. Antimicrobial resistance profiles and clonal relatedness of clinical isolates were also determined. We found that 34.2% (163/477) of the isolates were tellurite resistant, and among them 102 hvKp isolates detected with iucA or iutA or peg-344 as molecular markers. The bla (80.4%), followed by bla (76.5%) and bla (67.6%), bla (53.9%), and bla (32.3%) were detected, while bla was not present in any hvKp isolates. It was found that the majority of hvKp isolates belonged to capsular serotype K20 and ompK36 group C, which is related to clonal group (CG) 23 (e.g. ST23). A high percentage of multidrug-resistant hvKp (76.6%) and high resistance to imipenem (67%) indicated a serious problem that should be addressed in the clinical setting.
摘要
高毒力肺炎克雷伯菌（hvKp）已成为全球关注的病原体。本研究采用表型和基因型检测方法检测 hvKp。还测定了临床分离株的抗菌药物耐药谱和克隆相关性。我们发现，477 株分离株中有 34.2%（163/477）对亚碲酸盐具有耐药性，其中 102 株 hvKp 分离株用 iucA 或 iutA 或 peg-344 作为分子标记检测到。bla（80.4%），其次是 bla（76.5%）和 bla（67.6%），bla（53.9%）和 bla（32.3%），而任何 hvKp 分离株均未检测到 bla。发现大多数 hvKp 分离株属于荚膜血清型 K20 和ompK36 组 C，与克隆群（CG）23（例如 ST23）有关。高比例的多药耐药性 hvKp（76.6%）和对亚胺培南的高耐药性（67%）表明这是一个在临床环境中需要解决的严重问题。
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