通过蛋白质-蛋白质相互作用网络分析对烧伤损伤进行基因和生化途径评估
Gene and Biochemical Pathway Evaluation of Burns Injury via Protein-Protein Interaction Network Analysis.
作者信息
Rezaei-Tavirani Majid, Mansouri Vahid, Rezaei Tavirani Mostafa, Rostami-Nejad Mohammad, Bashash Davood, Zamanian Azodi Mona
机构信息
Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Galen Med J. 2019 Aug 7;8:e1257. doi: 10.31661/gmj.v8i0.1257. eCollection 2019.
BACKGROUND
Severe burns injury can affect several vital systems in the body and can cause inflammation in organs such as the heart, liver, and kidney. Many inflammatory mediators and regulatory hormones related to burn injuries are recognized. In this study, the genes related to burn injury interacted via network analysis, and the central nodes were enriched through gene ontology (GO).
MATERIALS AND METHODS
Disease query of STRING database was used for data gathering, and the network was constructed using Cytoscape software version 3.6.0. After gene screening, the central nodes were enriched via GO analysis by ClueGO. The highlighted genes and pathways were clustered and analyzed in detail.
RESULTS
Among 1067 genes, 35 critical genes that are involved in the 14 highlighted biochemical pathways were recognized. Interpretation of the finding indicates that a number of central genes can be considered as potential biomarkers related to burn injury.
CONCLUSION
Can we revise to "Burn injuries have features that are common to several diseases and increases their risk.
背景
严重烧伤会影响身体的多个重要系统，并可导致心脏、肝脏和肾脏等器官发生炎症。许多与烧伤相关的炎症介质和调节激素已被确认。在本研究中，通过网络分析确定了与烧伤相关的基因，并通过基因本体论（GO）对中心节点进行了富集分析。
材料与方法
利用STRING数据库的疾病查询功能收集数据，并使用Cytoscape 3.6.0软件构建网络。基因筛选后，通过ClueGO的GO分析对中心节点进行富集。对突出显示的基因和通路进行聚类并详细分析。
结果
在1067个基因中，识别出了参与14条突出显示的生化通路的35个关键基因。对这一发现的解读表明，一些中心基因可被视为与烧伤相关的潜在生物标志物。
结论
我们能否修改为“烧伤具有几种疾病共有的特征，并增加了它们的风险”。
你提供的英文原文中最后一句“CONCLUSION: Can we revise to "Burn injuries have features that are common to several diseases and increases their risk.” 似乎存在一些表述不太准确或完整的情况，不太明确其确切意图，翻译时尽量贴近原文进行了翻译。 同时，你提供的内容中“Can we revise to...”这样的表述放在这里有点突兀，可能是文本存在一些问题。如果还有其他疑问或需要进一步的帮助，请随时告诉我。
Zotero 插件