Hamzeloo-Moghadam Maryam, Rezaei Tavirani Mostafa, Jahani-Sherafat Somayeh, Rezaei Tavirani Sina, Esmaeili Somayeh, Ansari Mojtaba, Ahmadzadeh Alireza
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterol Hepatol Bed Bench. 2021 Fall;14(4):334-341.
To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study.
Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion.
Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings.
Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole.
In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required.
评估奥美拉唑对人体心血管系统的影响是本研究的主要目的。
奥美拉唑作为一种质子泵抑制剂被广泛用于抑制胃酸分泌。
从基因表达综合数据库（GEO）下载在有和没有奥美拉唑情况下的“人冠状动脉内皮细胞”的基因表达谱。差异表达基因（DEGs）作为一个相互作用组进行相互作用，并确定枢纽节点。通过基因本体（GO）分析对DEGs进行富集。根据GO研究结果确定关键枢纽。
在103个查询的DEGs中，61个个体包含在主要连通组件中。CTNNB1、HNRNPA1、SRSF4、TRA2A、SFPQ和RBM5基因被确定为关键枢纽基因。引入了六组生物学术语作为存在奥美拉唑时的失调元素。
总之，长期服用奥美拉唑可能会伴有不良影响，然而还需要更多证据。
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