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expression is associated with impaired autophagy and mitophagy in astrocytes.

作者信息

Eran Schmukler, Ronit Pinkas-Kramarski

机构信息

Department of Neurobiology, School of Neurobiology Biochemistry and Biophysics, Tel-Aviv University, Ramat-Aviv, Israel.

出版信息

Neural Regen Res. 2022 Apr;17(4):777-778. doi: 10.4103/1673-5374.322452.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09bf/8530113/c511771199d3/NRR-17-777-g001.jpg

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本文引用的文献

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Cell Death Dis. 2020 Jul 24;11(7):578. doi: 10.1038/s41419-020-02776-4.
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The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo.
J Alzheimers Dis. 2019;70(3):861-875. doi: 10.3233/JAD-190074.
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Nat Neurosci. 2019 Mar;22(3):401-412. doi: 10.1038/s41593-018-0332-9. Epub 2019 Feb 11.
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Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs.
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Impaired Autophagy in APOE4 Astrocytes.
J Alzheimers Dis. 2016;51(3):915-27. doi: 10.3233/JAD-151101.
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Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease.
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