Marina Raguž, Department of Neurosurgery, Dubrava University Hospital, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia,
Croat Med J. 2021 Aug 31;62(4):318-327. doi: 10.3325/cmj.2021.62.318.
To report the outcomes of robot-assisted brain biopsies performed using a novel RONNA G4 system. The system was developed by a research group from the Faculty of Mechanical Engineering and Naval Architecture and a team of neurosurgeons from Dubrava University Hospital, University of Zagreb School of Medicine.
This prospective study included 49 biopsies analyzed during one year: 23 robotic frameless and 26 frame-based Leksell stereotactic biopsies. We analyzed the presenting symptoms, tumor range and location, postoperative complications, pathohistological diagnosis, diagnostic yield, as well as operation and hospitalization duration. The target point error was calculated to assess the accuracy of the RONNA system.
No postoperative mortality, morbidity, or infections were observed. In the frameless robotic biopsy group, only one pathohistological diagnosis was inconclusive. Therefore, the diagnostic yield was 95.6% (22/23), similar to that of the framebased Leksell stereotactic biopsy group (95.1% or 25/26). The average target point error in the frameless robotic biopsy group was 2.15±1.22 mm (range 0.39-5.85).
The RONNA G4 robotic system is a safe and accurate tool for brain biopsy, although further research warrants a larger patient sample, comparison with other robotic systems, and a systematic analysis of the entry and target point errors.
报告使用新型 RONNA G4 系统进行机器人辅助脑活检的结果。该系统由萨格勒布大学机械工程与船舶建筑学院的一个研究小组和杜布拉瓦大学医院的神经外科团队共同开发。
本前瞻性研究纳入了一年内分析的 49 例活检：23 例无框架机器人和 26 例框架 Leksell 立体定向活检。我们分析了患者的首发症状、肿瘤范围和位置、术后并发症、病理组织学诊断、诊断率以及手术和住院时间。计算了靶点误差，以评估 RONNA 系统的准确性。
无术后死亡、发病率或感染。在无框架机器人活检组中，仅有 1 例病理组织学诊断不明确。因此，诊断率为 95.6%（22/23），与框架 Leksell 立体定向活检组（95.1%或 25/26）相似。无框架机器人活检组的平均靶点误差为 2.15±1.22mm（范围 0.39-5.85）。
RONNA G4 机器人系统是一种安全、准确的脑活检工具，尽管需要进一步的研究，包括更大的患者样本、与其他机器人系统的比较以及对入路和靶点误差的系统分析。
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