Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China.
J Clin Sleep Med. 2022 Feb 1;18(2):653-662. doi: 10.5664/jcsm.9642.
Shift work is commonly increasing, and some physiological changes occur as workers sleep less and their circadian rhythms are disrupted. This umbrella review not only summarizes the evidence but also evaluates the validity of the associations of shift work with different health outcomes.
We searched the MEDLINE, Web of Science, and Embase databases from their inception to April 25, 2020. For each systematic review and/or meta-analysis, we estimated the summary effect size, the 95% confidence interval, the 95% prediction interval, the between-study heterogeneity, evidence of small-study effects, and evidence of excess-significance bias.
Eight eligible systematic reviews and meta-analyses were identified, providing data on 16 associations. We observed highly suggestive evidence for associations between shift work and myocardial infarction (having ever vs having never done shift work) and diabetes mellitus incidence (per 5-year increment in shift work). Furthermore, we observed suggestive evidence for an association between shift work and diabetes mellitus incidence (having ever vs having never done shift work). Two health outcomes, including prostate cancer incidence (having ever vs having never done shift work and rotating night shift work vs daytime work) and colorectal cancer incidence (longest vs shortest shift work time), were only supported by weak evidence.
This umbrella review found that shift work was associated with several health outcomes with different levels of evidence. Associations for myocardial infarction and diabetes mellitus incidence were supported by highly suggestive evidence.
Registry: PROSPERO; Identifier: CRD42020188537.
Wu Q-J, Sun H, Wen Z-Y, et al. Shift work and health outcomes: an umbrella review of systematic reviews and meta-analyses of epidemiological studies. 2022;18(2):653-662.
轮班工作越来越普遍，由于工人睡眠减少和昼夜节律紊乱，会发生一些生理变化。本综述不仅总结了证据，还评估了轮班工作与不同健康结果之间关联的有效性。
我们从建库到 2020 年 4 月 25 日在 MEDLINE、Web of Science 和 Embase 数据库中进行了检索。对于每个系统评价和/或荟萃分析，我们估计了汇总效应大小、95%置信区间、95%预测区间、研究间异质性、小样本研究效应的证据和过度显著性偏倚的证据。
确定了 8 项符合条件的系统评价和荟萃分析，提供了 16 项关联的数据。我们观察到轮班工作与心肌梗死（曾经轮班工作与从未轮班工作）和糖尿病发病率（轮班工作每增加 5 年）之间存在高度提示性关联的证据。此外，我们观察到轮班工作与糖尿病发病率（曾经轮班工作与从未轮班工作）之间存在关联的提示性证据。只有前列腺癌发病率（曾经轮班工作与从未轮班工作和轮班夜班工作与白天工作）和结直肠癌发病率（最长轮班工作时间与最短轮班工作时间）这两个健康结果仅得到弱证据的支持。
本综述发现，轮班工作与几种健康结果有关，证据水平不同。心肌梗死和糖尿病发病率的关联有高度提示性证据支持。
PROSPERO；注册号：CRD42020188537。
Wu Q-J, Sun H, Wen Z-Y, et al. Shift work and health outcomes: an umbrella review of systematic reviews and meta-analyses of epidemiological studies. 2022;18(2):653-662.
