Colditz I G, Maas P J
CSIRO, Division of Animal Health, NSW, Australia.
Immunol Cell Biol. 1987 Dec;65 ( Pt 6):433-6. doi: 10.1038/icb.1987.51.
Infusion of zymosan-activated plasma (ZAP), a source of activated complement, induced inflammation in non-lactating mammary glands but not in lactating glands of ewes and cows. Interstitial injection of ZAP in lactating ovine glands also failed to induce inflammation as assessed by the neutrophil content of milk. The inflammatory activity of ZAP in non-lactating glands was inhibited by infusion of whole milk but not by skimmed milk. These results suggest that components of whole milk mask the inflammatory activity of activated complement. In addition, lactating mammary tissue of ewes and cows may lack sensitivity to the inflammatory effect of activated complement. Thus, activated complement cannot be an important mediator of inflammation in the lactating gland.
注入酵母聚糖激活血浆（ZAP，一种激活补体的来源）会在母羊和奶牛的非泌乳乳腺中引发炎症，但在泌乳乳腺中却不会。通过乳汁中的中性粒细胞含量评估发现，向泌乳的绵羊乳腺间质注射ZAP也未能引发炎症。全脂牛奶注入可抑制ZAP在非泌乳乳腺中的炎症活性，而脱脂牛奶则无此作用。这些结果表明，全脂牛奶的成分掩盖了激活补体的炎症活性。此外，母羊和奶牛的泌乳乳腺组织可能对激活补体的炎症作用缺乏敏感性。因此，激活补体不可能是泌乳乳腺炎症的重要介质。
