Colditz I G
CSIRO Division of Animal Health, Armidale, N.S.W., Australia.
Q J Exp Physiol. 1988 May;73(3):363-8. doi: 10.1113/expphysiol.1988.sp003152.
Cessation of lactation, initiated by the removal of lambs from their mothers, induced an inflammatory response with elevated numbers of neutrophil leucocytes in mammary secretions being detected within 16 h. Leucocyte numbers were still elevated 7 d later. Infusion of whole milk into non-lactating glands caused no change in leucocyte numbers after 24 h. Involution secretions, however, had the capacity to induce an inflammatory response when infused into non-lactating glands. Daily infusion of endotoxin (100 ng) into non-lactating glands resulted in a marked attenuation of the inflammatory response. Such desensitization did not accompany reinfusion of involution secretion. Responses to involution secretion were enhanced in glands desensitized to endotoxin. The failure of desensitization to develop in glands receiving repeated infusions of involution secretion and the lack of cross-desensitization between involution secretion and endotoxin indicate that a novel mediator of inflammation may be produced during mammary involution in sheep.
将羔羊与母羊分开导致泌乳停止，引发了炎症反应，在16小时内检测到乳腺分泌物中嗜中性白细胞数量增加。7天后白细胞数量仍居高不下。向非泌乳腺体注入全脂牛奶24小时后白细胞数量没有变化。然而，退化期分泌物注入非泌乳腺体时能够引发炎症反应。每天向非泌乳腺体注入内毒素（100纳克）会导致炎症反应明显减弱。再次注入退化期分泌物时并未出现这种脱敏现象。对内毒素脱敏的腺体对退化期分泌物的反应增强。接受反复注入退化期分泌物的腺体未能产生脱敏现象，且退化期分泌物与内毒素之间缺乏交叉脱敏现象，这表明绵羊乳腺退化过程中可能会产生一种新的炎症介质。
