Institute of Comparative Molecular Endocrinology, University of Ulm, Ulm, Germany.
Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine, Münster, Germany.
Nat Rev Rheumatol. 2021 Oct;17(10):608-620. doi: 10.1038/s41584-021-00682-3. Epub 2021 Sep 3.
Blood vessels form a versatile transport network that is best known for its critical roles in processes such as tissue oxygenation, metabolism and immune surveillance. The vasculature also provides local, often organ-specific, molecular signals that control the behaviour of other cell types in their vicinity during development, homeostasis and regeneration, and also in disease processes. In the skeletal system, the local vasculature is actively involved in both bone formation and resorption. In addition, blood vessels participate in inflammatory processes and contribute to the pathogenesis of diseases that affect the joints, such as rheumatoid arthritis and osteoarthritis. This Review summarizes the current understanding of the architecture, angiogenic growth and functional properties of the bone vasculature. The effects of ageing and pathological conditions, including arthritis and osteoporosis, are also discussed.
血管形成了一个多功能的运输网络，其在组织氧合、代谢和免疫监视等过程中发挥着关键作用，这一点最为人所知。血管系统还提供局部的、通常是器官特异性的分子信号，在发育、稳态和再生过程中以及在疾病过程中控制其附近其他细胞类型的行为。在骨骼系统中，局部血管系统积极参与骨形成和骨吸收。此外，血管参与炎症过程，并有助于影响关节的疾病（如类风湿关节炎和骨关节炎）的发病机制。这篇综述总结了目前对骨骼血管系统的结构、血管生成生长和功能特性的理解。还讨论了衰老和病理状况（包括关节炎和骨质疏松症）的影响。
