Gurwith M, Hinde D, Gross R, Rowe B
J Infect Dis. 1978 Mar;137(3):292-7. doi: 10.1093/infdis/137.3.292.
The rate of isolation of Escherichia coli belonging to the traditional serotypes enteropathogenic for infants was studied prospectively in two groups. Group 1 consisted of children with diarrhea and of controls without gastrointestinal disease who were matched for age and inpatient or outpatient status. Group 2 consisted of families entered in a prospective study of rotavirus infections. In group 1 enteropathogenic Escherichia coli were found in 13 (6%) of 220 children younger than 12 months of age and in nine (6%) of 143 children 12--35 months of age, all of whom had diarrhea. Enteropathogenic E. coli were found in only one of an equal number of matched controls (P = 0.002 and 0.004, respectively). In group 2 enteropathogenic E. coli were present in seven (18%) of 38 specimens obtained during diarrheal episodes, as compared with five (1%) of 492 specimens obtained when there was no diarrhea (P less than 0.001). The enteropathogenic E. coli isolated were not enterotoxigenic. The most common serogroup was O111, but many different O:H serotypes were detected. Thus, the association of enteropathogenic E. coli with endemic diarrhea was significant, even though no enteropathogenic mechanism was apparent.
前瞻性地研究了两组中属于对婴儿有致病性的传统血清型大肠杆菌的分离率。第一组由腹泻儿童和无胃肠道疾病的对照儿童组成，两组在年龄以及住院或门诊状态方面进行了匹配。第二组由参与轮状病毒感染前瞻性研究的家庭组成。在第一组中，在220名12个月以下的儿童中有13名（6%）以及143名12至35个月的儿童中有9名（6%）发现了致病性大肠杆菌，所有这些儿童均患有腹泻。在数量相等的匹配对照中仅在1名儿童中发现了致病性大肠杆菌（P值分别为0.002和0.004）。在第二组中，腹泻发作期间采集的38份标本中有7份（18%）存在致病性大肠杆菌，而无腹泻时采集的492份标本中有5份（1%）存在致病性大肠杆菌（P<0.001）。分离出的致病性大肠杆菌不产肠毒素。最常见的血清群是O111，但检测到许多不同的O:H血清型。因此，即使没有明显的致病机制，致病性大肠杆菌与地方性腹泻之间的关联也是显著的。
