School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales CF10 3AT, UK.
School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales CF10 3AT, UK.
Neurobiol Learn Mem. 2021 Nov;185:107516. doi: 10.1016/j.nlm.2021.107516. Epub 2021 Sep 3.
Retrosplenial cortex contains two principal subdivisions, area 29 (granular) and area 30 (dysgranular). Their respective anatomical connections in the rat brain reveal that area 29 is the primary recipient of hippocampal and parahippocampal spatial and contextual information while area 30 is the primary interactor with current visual information. Lesion studies and measures of neuronal activity in rodents indicate that retrosplenial cortex helps to integrate space from different perspectives, e.g., egocentric and allocentric, providing landmark and heading cues for navigation and spatial learning. It provides a repository of scene information that, over time, becomes increasingly independent of the hippocampus. These processes, reflect the interactive actions between areas 29 and 30, along with their convergent influences on cortical and thalamic targets. Consequently, despite their differences, both areas 29 and 30 are necessary for an array of spatial and learning problems.
后扣带回皮质包含两个主要的分区，29 区（颗粒状）和 30 区（粒层缺失）。在大鼠大脑中的各自解剖连接揭示了 29 区是海马和海马旁区空间和上下文信息的主要接收区，而 30 区是与当前视觉信息的主要交互区。损伤研究和啮齿动物神经元活动的测量表明，后扣带回皮质有助于整合来自不同视角的空间，例如自我中心和他心，为导航和空间学习提供地标和朝向提示。它提供了一个场景信息的存储库，随着时间的推移，该信息越来越独立于海马体。这些过程反映了 29 区和 30 区之间的相互作用，以及它们对皮质和丘脑靶区的收敛影响。因此，尽管存在差异，但 29 区和 30 区对于一系列空间和学习问题都是必要的。
