Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Korean J Intern Med. 2022 Jan;37(1):73-84. doi: 10.3904/kjim.2020.386. Epub 2021 Sep 6.
BACKGROUND/AIMS: Data on the immunoprotective status against measles, mumps, rubella, varicella zoster virus (VZV), hepatitis A virus (HAV), and Epstein-Barr virus (EBV) infection in patients with inflammatory bowel disease (IBD) are still lacking. Therefore, we investigated the seropositivity rates for viral infectious diseases and the associated factors in Korean patients with IBD.
In this retrospective cohort study, serum immunoglobulin G antibody positivity rates against measles virus, mumps virus, rubella virus, VZV, HAV, and EBV viral capsid antigen (VCA) were measured in patients with Crohn's disease or ulcerative colitis (UC) who first visited the IBD clinic. Seropositivity rates and their associated factors were analyzed.
Between January 2016 and December 2018, 263 patients were enrolled (male, 167 [67.3%]; UC, 134 [50.9%]). The median age at serological test was 30 years (interquartile range, 22 to 46). The seropositivity rates were 84.0%, 85.2%, 66.5%, 87.4%, 50.0%, and 93.7% for measles, mumps, rubella, VZV, HAV, and EBV, respectively. Younger age at serological test was associated with seronegative status for measles (adjusted odds ratio [aOR], 0.92; 95% confidence interval [CI], 0.88 to 0.96), VZV (aOR, 0.83; 95% CI, 0.74 to 0.93), and HAV (aOR, 0.93; 95% CI, 0.91 to 0.95). Furthermore, IBD type-UC was associated with seronegative status against VZV (aOR, 0.33; 95% CI, 0.11 to 0.99).
Seropositivity rates for common viral infectious diseases in Korean patients with IBD were similar to those of the general population. In the younger age group, protective immunity against measles, VZV, and HAV is required, with proper vaccination, as necessary.
背景/目的：关于炎症性肠病（IBD）患者对麻疹、腮腺炎、风疹、水痘带状疱疹病毒（VZV）、甲型肝炎病毒（HAV）和 Epstein-Barr 病毒（EBV）感染的免疫保护状态的数据仍然缺乏。因此，我们调查了韩国 IBD 患者的病毒性传染病血清阳性率及其相关因素。
在这项回顾性队列研究中，对首次就诊于 IBD 门诊的克罗恩病或溃疡性结肠炎（UC）患者的麻疹病毒、腮腺炎病毒、风疹病毒、VZV、HAV 和 EBV 病毒衣壳抗原（VCA）的血清 IgG 抗体阳性率进行了测量。分析了血清阳性率及其相关因素。
2016 年 1 月至 2018 年 12 月期间，共纳入 263 名患者（男性 167 名[67.3%]；UC 患者 134 名[50.9%]）。血清学检测的中位年龄为 30 岁（四分位间距 22 至 46）。麻疹、腮腺炎、风疹、VZV、HAV 和 EBV 的血清阳性率分别为 84.0%、85.2%、66.5%、87.4%、50.0%和 93.7%。血清学检测年龄较小与麻疹（调整优势比[aOR]，0.92；95%置信区间[CI]，0.88 至 0.96）、VZV（aOR，0.83；95% CI，0.74 至 0.93）和 HAV（aOR，0.93；95% CI，0.91 至 0.95）的血清阴性状态相关。此外，IBD 类型 UC 与 VZV 血清阴性状态相关（aOR，0.33；95% CI，0.11 至 0.99）。
韩国 IBD 患者常见病毒性传染病的血清阳性率与一般人群相似。在年龄较小的人群中，需要对麻疹、VZV 和 HAV 进行适当的疫苗接种，以建立保护免疫力。
