Liu Yiwen, Wu Qing, Wan Dongmei, He Huiqin, Lin Hailian, Wang Kelang, Que Genxiang, Wang Yuanyuan, Chen Yongjun, Tang Xiaoqing, Wu Lingbo, Yang Xuefeng
The Affifiliated Nanhua Hospital, Department of Gastroenterology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
The Affifiliated Nanhua Hospital, Department of General Practice, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Evid Based Complement Alternat Med. 2021 Aug 25;2021:6949902. doi: 10.1155/2021/6949902. eCollection 2021.
Angiotensin-converting enzyme 2 (ACE2) has been identified as the key receptor of SARS coronavirus that plays a key role in the pathogenesis of SARS. It is known that ACE2 mRNA can be expressed in most organs. However, the protein expression of ACE2 is not clear yet. To explore the role of ACE2 as a precipitating factor in digestive organ damage in COVID-19, this study investigated the expression of ACE2 protein in the human liver, esophagus, stomach, and colon. The result showed that ACE2 can be expressed in the liver, esophagus, stomach, and colon, which suggests SARS-CoV-2 may enter the digestive system through ACE2 and cause liver damage and gastrointestinal damage. It is hoped that the result of the study will provide a new strategy for the prevention and treatment of digestive organ damage under COVID-19.
血管紧张素转换酶2（ACE2）已被确定为严重急性呼吸综合征冠状病毒（SARS-CoV）的关键受体，在SARS发病机制中起关键作用。已知ACE2信使核糖核酸（mRNA）可在大多数器官中表达。然而，ACE2的蛋白表达情况尚不清楚。为探究ACE2作为2019冠状病毒病（COVID-19）消化器官损伤诱发因素的作用，本研究调查了ACE2蛋白在人肝脏、食管、胃和结肠中的表达。结果显示，ACE2可在肝脏、食管、胃和结肠中表达，这表明严重急性呼吸综合征冠状病毒2（SARS-CoV-2）可能通过ACE2进入消化系统并导致肝损伤和胃肠道损伤。希望该研究结果能为COVID-19下消化器官损伤的防治提供新策略。
