Behboudi E, Hamidi V, Gholizadeh F, Grala E M, Ghelmani Y, Nakhaie M, Charostad J, Astani A
Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran.
Department of Statistical and Actuarial Sciences, University of Western Ontario, London, Ontario, Canada.
New Microbes New Infect. 2021 Nov;44:100934. doi: 10.1016/j.nmni.2021.100934. Epub 2021 Sep 1.
Blood group antigens are one of the most important antigens in humans that have an impact on susceptibility to disease and may be used as a prognosis factor in different diseases such as COVID-19. The study aimed to investigate the relationship between ABO blood groups and Rhesus antigen and susceptibility to COVID-19. The clinical data of 398 subjects were used in the investigation collected from 148 cases vs. 250 controls. This information was obtained from Shahid Sadoughi Hospital of Yazd (IRAN) University. Blood groups and outcomes were assessed using statistical tests for four populations: COV + vs. COV- and COV +/deceased vs. COV +/live. Out of a total of 148 COVID-19 patients, 80 (54/1%) were male, 68 (45/9%) were female. Among these patients, 33 (22/6%) had type A+, 44 (30/1%) had type B+, 13 (8/9%) had type AB+, and 36 (24/7%) had type O+. On the other hand, out of 148 patients, 126 (86/3%) had positive blood types, and 20 (13/7%) had negative blood types. As a result, no significant difference was found in the relationship between ABO blood groups and RH type and susceptibility to COVID-19 (p-value = 0.392 and p-value = 0.847, respectively). Other data showed a significant difference between patients group with other parameters such as age (p-value<0.001) and gender (p-value<0.001). Although in this study there was no association between blood type and RH type with COVID-19, findings of the association between age and gender can confirm the results of previous studies.
血型抗原是人类最重要的抗原之一，它会影响疾病易感性，并且可作为不同疾病（如新冠病毒病）的预后因素。该研究旨在调查ABO血型和恒河猴抗原与新冠病毒病易感性之间的关系。调查使用了从148例病例与250例对照中收集的398名受试者的临床数据。这些信息来自伊朗亚兹德的沙希德·萨杜基医院。使用统计检验对四组人群评估血型和结果：新冠病毒病阳性组与新冠病毒病阴性组，以及新冠病毒病阳性/死亡组与新冠病毒病阳性/存活组。在总共148例新冠病毒病患者中，80例（54.1%）为男性，68例（45.9%）为女性。在这些患者中，33例（22.6%）为A型阳性，44例（30.1%）为B型阳性，13例（8.9%）为AB型阳性，36例（24.7%）为O型阳性。另一方面，在148例患者中，126例（86.3%）血型为阳性，20例（13.7%）血型为阴性。结果发现，ABO血型与RH血型和新冠病毒病易感性之间没有显著差异（p值分别为0.392和0.847）。其他数据显示，患者组在年龄（p值<0.001）和性别（p值<0.001）等其他参数上存在显著差异。尽管在本研究中血型和RH血型与新冠病毒病之间没有关联，但年龄和性别之间关联的研究结果可以证实先前研究的结果。
