D614G突变出现在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的所有感兴趣病毒株（VOI）和变异株（VOC）中：它是达尔文开创的正选择的一部分吗？
D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin?
作者信息
Chakraborty Chiranjib, Saha Abinit, Sharma Ashish Ranjan, Bhattacharya Manojit, Lee Sang-Soo, Agoramoorthy Govindasamy
机构信息
Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore RD, Kolkata, West Bengal 700126, India.
Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, 24252, Gangwon-do, Republic of Korea.
出版信息
Mol Ther Nucleic Acids. 2021 Dec 3;26:237-241. doi: 10.1016/j.omtn.2021.07.011. Epub 2021 Sep 1.
Recently, several emerging variants of SARS-CoV-2 have originated from the Wuhan strain and spread throughout the globe within one and a half years. One mutation, D614G, is very prominent in all VOI and VOC in SARS-CoV-2. This mutation might help to increase the viral fitness in all emerging variants where the mutation is present. With the help of this mutation (D614G), the SARS-CoV-2 variants have gained viral fitness to enhance viral replication and increase transmission. This paper attempts to answer the question of whether the mutation (D614G) occurs due to positive selection or not.
最近，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的几种新出现的变体源自武汉毒株，并在一年半的时间里传播到全球。一种突变，即D614G，在SARS-CoV-2的所有感兴趣变体（VOI）和值得关注变体（VOC）中非常突出。这种突变可能有助于提高所有存在该突变的新出现变体中的病毒适应性。借助这种突变（D614G），SARS-CoV-2变体获得了病毒适应性，以增强病毒复制并增加传播。本文试图回答突变（D614G）是否由于正选择而发生这一问题。
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