Xia Xuyun, Xue Shiyao, Yang Gangyi, Li Yu, Liu Hua, Chen Chen, Li Ling
The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
PeerJ. 2021 Aug 20;9:e11869. doi: 10.7717/peerj.11869. eCollection 2021.
Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women with pre-diabetes and to analyze the relationship between fetuin-B and the occurrence and development of IR.
A total of 304 women were enrolled in this study and subjected to both OGTT and EHC. A subgroup of 26 overweight/obese womenwas treated with Lira for 24 weeks. serum fetuin-B concentrations were measured by ELISA.
In IGT and IR-NG groups, serum fetuin-B levels were higher than those in the NGT group. The serum fetuin-B levels in the IGT group were higher than those in the IR-NG group. serum fetuin-B was positively correlated with BMI, WHR, 2h-BG, FIns, HbA1c, and HOMA2-IR, but negatively correlated with the M-value in all study populations. Multiple stepwise regression analysis showed that the M-value was independently and inversely associated with serum fetuin-B. Logistic regression analysis showed that serum fetuin-B was independently associated with IGT and significantly increased the risk of IGT. During the OGTT, serum fetuin-B increased significantly in the NGT group, but there were no significant changes in other groups. During the EHC, serum fetuin-B increased in the IGT group, but there was no change in other groups. After Lira intervention, serum fetuin-B decreased significantly in IGT women.
serum fetuin-B levels are elevated in young women with IR or IGT and may be associated with IR.
据报道，胎球蛋白B参与葡萄糖和脂质代谢，并与糖尿病的发生有关。本研究的主要目的是探讨糖尿病前期年轻女性循环胎球蛋白B的变化，并分析胎球蛋白B与胰岛素抵抗（IR）发生发展的关系。
本研究共纳入304名女性，均接受口服葡萄糖耐量试验（OGTT）和高胰岛素-正葡萄糖钳夹试验（EHC）。26名超重/肥胖女性亚组接受利拉鲁肽治疗24周。采用酶联免疫吸附测定法（ELISA）检测血清胎球蛋白B浓度。
在糖耐量受损（IGT）组和非糖耐量正常胰岛素抵抗（IR-NG）组中，血清胎球蛋白B水平高于糖耐量正常（NGT）组。IGT组的血清胎球蛋白B水平高于IR-NG组。在所有研究人群中，血清胎球蛋白B与体重指数（BMI）、腰臀比（WHR）、2小时血糖（2h-BG）、空腹胰岛素（FIns）、糖化血红蛋白（HbA1c）和稳态模型评估的胰岛素抵抗指数（HOMA2-IR）呈正相关，但与M值呈负相关。多元逐步回归分析显示，M值与血清胎球蛋白B独立且呈负相关。逻辑回归分析显示，血清胎球蛋白B与IGT独立相关，并显著增加IGT风险。在OGTT期间，NGT组血清胎球蛋白B显著升高，但其他组无显著变化。在EHC期间，IGT组血清胎球蛋白B升高，但其他组无变化。利拉鲁肽干预后，IGT女性血清胎球蛋白B显著降低。
IR或IGT的年轻女性血清胎球蛋白B水平升高，可能与IR有关。
