Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Zunyi, 563003, Guizhou, China.
Chongqing Prevention and Treatment Hospital for Occupational Diseases, Chongqing, China.
BMC Endocr Disord. 2020 May 19;20(1):67. doi: 10.1186/s12902-020-0538-1.
Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent.
Two hundred seven subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. Spearman's correlation analysis was used to examine the association of the serum Fetuin-A with other parameters.
Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 μg/L for most women without PCOS (95%). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 μg/L.
Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.
胰岛素抵抗（IR）是多囊卵巢综合征（PCOS）患者的常见特征。有报道称，循环胎球蛋白-A 水平与 IR 和 2 型糖尿病（T2DM）有关。然而，之前的报道并不一致。
根据鹿特丹共识标准的诊断指南，对 207 例患者进行了 PCOS 筛查。使用 ELISA 试剂盒测量血清胎球蛋白-A 水平。采用独立 t 检验或非参数检验检测 PCOS 组和对照组之间的差异。采用 Spearman 相关分析检测血清胎球蛋白-A 与其他参数的相关性。
我们的研究结果表明，大多数无 PCOS 的女性（95%）的循环胎球蛋白-A 浓度范围为 196.6-418.2μg/L。与健康女性相比，PCOS 女性的循环胎球蛋白-A 水平更高（437.9±119.3 vs. 313.8±60.5μg/L；p<0.01）。血清胎球蛋白-A 与 BMI、WHR、TG、TC、LDL-C、HOMA-IR、LH、T 和 DHEA-S 呈正相关。多元回归分析表明，WHR、TG、HOMA-IR 和 DHEA-S 是循环胎球蛋白-A 水平的独立预测因素。二项逻辑回归显示，血清胎球蛋白-A 与 PCOS 的发生有关。此外，我们的 ROC 曲线分析发现，胎球蛋白-A 预测 PCOS 和 IR 的截断值分别为 366.3 和 412.6μg/L。
血液胎球蛋白-A 可能是筛查 PCOS 和 IR 女性的有用生物标志物。
