抑制 PP2Ac 通过 ATM/METTL3 轴促进胃癌细胞的恶性表型。
Inhibiting PP2Ac Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis.
机构信息
Department of General Surgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China.
Department of Central Laboratory, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China.
出版信息
Biomed Res Int. 2021 Aug 24;2021:1015293. doi: 10.1155/2021/1015293. eCollection 2021.
This article is aimed at exploring the relationship between the phosphatase 2A catalytic subunit C (PP2Ac, encoded by ) and methyltransferase-like 3 (METTL3) in the malignant progression of gastric cancer (GC). Through analyzing the bioinformatics database and clinical tissue immunohistochemistry results, we found that abnormal PP2Ac and METTL3 levels were closely related to the malignant progression of GC. To explore the internal connection between PP2Ac and METTL3 in the progression of GC, we carried out cellular and molecular experiments and finally proved that PP2Ac inhibition can upregulate METTL3 levels by activating ATM activity, thereby promoting the malignant progression of GC.
本文旨在探讨磷酸酶 2A 催化亚基 C（PP2Ac，由 编码）与甲基转移酶样 3（METTL3）在胃癌（GC）恶性进展中的关系。通过分析生物信息学数据库和临床组织免疫组织化学结果，我们发现异常的 PP2Ac 和 METTL3 水平与 GC 的恶性进展密切相关。为了探讨 PP2Ac 和 METTL3 在 GC 进展中的内在联系，我们进行了细胞和分子实验，最终证明 PP2Ac 抑制通过激活 ATM 活性上调 METTL3 水平，从而促进 GC 的恶性进展。
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