Zhang Yuliang, Chen Wenjie, Zheng Xiwang, Guo Yujia, Cao Jimin, Zhang Yu, Wen Shuxin, Gao Wei, Wu Yongyan
Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, No. 85, South Jiefang Road, Taiyuan 030001, Shanxi, China.
Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Mol Ther Oncolytics. 2021 May 19;22:52-63. doi: 10.1016/j.omto.2021.05.003. eCollection 2021 Sep 24.
Metabolic diseases caused by disorders in amino acids, glucose, lipid metabolism, and other metabolic risk factors show high incidences in young people, and current treatments are ineffective. -methyladenosine (mA) RNA modification is a post-transcriptional regulation of gene expression with several effects on physiological processes and biological functions. Recent studies report that mA RNA modification is involved in various metabolic pathways and development of common metabolic diseases, making it a potential disease-specific therapeutic target. This review explores components, mechanisms, and research methods of mA RNA modification. In addition, we summarize the progress of research on mA RNA modification in metabolism-related human diseases, including diabetes, obesity, non-alcoholic fatty liver disease, osteoporosis, and cancer. Furthermore, opportunities and the challenges facing basic research and clinical application of mA RNA modification in metabolism-related human diseases are discussed. This review is meant to enhance our understanding of the molecular mechanisms, research methods, and clinical significance of mA RNA modification in metabolism-related human diseases.
由氨基酸、葡萄糖、脂质代谢紊乱及其他代谢风险因素引起的代谢性疾病在年轻人中发病率很高，且目前的治疗方法效果不佳。N6-甲基腺苷（m6A）RNA修饰是一种基因表达的转录后调控，对生理过程和生物学功能有多种影响。最近的研究报告称，m6A RNA修饰参与各种代谢途径和常见代谢疾病的发展，使其成为潜在的疾病特异性治疗靶点。本综述探讨了m6A RNA修饰的组成成分、机制和研究方法。此外，我们总结了m6A RNA修饰在代谢相关人类疾病（包括糖尿病、肥胖症、非酒精性脂肪性肝病、骨质疏松症和癌症）中的研究进展。此外，还讨论了m6A RNA修饰在代谢相关人类疾病的基础研究和临床应用中面临的机遇和挑战。本综述旨在加深我们对m6A RNA修饰在代谢相关人类疾病中的分子机制、研究方法和临床意义的理解。
