Abel John H, Lecamwasam Kimaya, Hilaire Melissa A St, Klerman Elizabeth B
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114.
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Curr Opin Physiol. 2020 Jun;15:37-46. doi: 10.1016/j.cophys.2019.12.001. Epub 2019 Dec 13.
In the past few decades, advances in understanding sleep-wake neurophysiology have occurred hand-in-hand with advances in mathematical modeling of sleep and wake. In this review, we summarize recent updates in modeling the timing and durations of sleep and wake, the underlying neurophysiology of sleep and wake, and the application of these models in understanding cognition and disease. Throughout, we highlight the role modeling has played in developing our understanding of sleep and its underlying mechanisms. We present open questions and controversies in the field and propose the utility of individualized models of sleep for precision sleep medicine.
在过去几十年里，睡眠 - 觉醒神经生理学理解方面的进展与睡眠和觉醒的数学建模进展齐头并进。在本综述中，我们总结了睡眠和觉醒时间及持续时间建模、睡眠和觉醒潜在神经生理学以及这些模型在理解认知和疾病方面应用的最新进展。在整个过程中，我们强调建模在发展我们对睡眠及其潜在机制理解方面所起的作用。我们提出了该领域的开放性问题和争议，并提出了个性化睡眠模型在精准睡眠医学中的实用性。
