CRC for Alertness, Safety and Productivity, Melbourne, Victoria, Australia.
School of Psychological Sciences and Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing & Health Sciences, Monash University, Clayton, Victoria, Australia.
Sci Rep. 2019 Jul 30;9(1):11032. doi: 10.1038/s41598-019-47290-6.
Practical alternatives to gold-standard measures of circadian timing in shift workers are needed. We assessed the feasibility of applying a limit-cycle oscillator model of the human circadian pacemaker to estimate circadian phase in 25 nursing and medical staff in a field setting during a transition from day/evening shifts (diurnal schedule) to 3-5 consecutive night shifts (night schedule). Ambulatory measurements of light and activity recorded with wrist actigraphs were used as inputs into the model. Model estimations were compared to urinary 6-sulphatoxymelatonin (aMT6s) acrophase measured on the diurnal schedule and last consecutive night shift. The model predicted aMT6s acrophase with an absolute mean error of 0.69 h on the diurnal schedule (SD = 0.94 h, 80% within ±1 hour), and 0.95 h on the night schedule (SD = 1.24 h, 68% within ±1 hour). The aMT6s phase shift from diurnal to night schedule was predicted to within ±1 hour in 56% of individuals. Our findings indicate the model can be generalized to a shift work setting, although prediction of inter-individual variability in circadian phase shift during night shifts was limited. This study provides the basis for further adaptation and validation of models for predicting circadian phase in rotating shift workers.
在轮班工人中，需要实用的替代金标准测量昼夜节律时间的方法。我们评估了将人体昼夜节律起搏器的限幅循环振荡器模型应用于估计 25 名护理和医务人员在从日间/傍晚班次（日常时间表）过渡到 3-5 个连续夜班（夜班时间表）期间的昼夜节律相位的可行性。使用腕部活动记录仪记录的昼夜光照和活动的动态测量值被用作模型的输入。将模型估算与在日常时间表和最后一个连续夜班测量的尿液 6-硫酸褪黑素（aMT6s）峰值进行比较。该模型在日常时间表上预测 aMT6s 峰值的绝对平均误差为 0.69 小时（SD=0.94 小时，80%在±1 小时内），在夜间时间表上为 0.95 小时（SD=1.24 小时，68%在±1 小时内）。在 56%的个体中，预测 aMT6s 从日常时间表到夜间时间表的相位变化在±1 小时内。我们的研究结果表明，该模型可以推广到轮班工作环境，尽管对夜间轮班期间个体间昼夜节律相位变化的预测存在局限性。本研究为进一步适应和验证预测轮班工人昼夜节律相位的模型提供了基础。
