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严重急性呼吸综合征冠状病毒2：生物学、检测、巨噬细胞介导的发病机制及潜在治疗方法

SARS-Cov-2: Biology, Detection, Macrophage Mediated Pathogenesis and Potential Treatments.

作者信息

Borges-Velez Gabriel, Rosario-Rodriguez Lester J, Rosado-Philippi Julio E, Cartagena Luz J, Garcia-Requena Luis, Gonzalez Andrea, Perez Jean, Melendez Loyda M

机构信息

Department of Microbiology and Medical Zoology, University of Puerto Rico, Medical Sciences Campus, USA.

Department of Biology, University of Puerto Rico, Rio Piedras Campus, USA.

出版信息

Virol Immunol J. 2020;4(2). doi: 10.23880/vij-16000242. Epub 2020 Jul 2.

DOI:10.23880/vij-16000242
PMID:34485853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8415769/
Abstract

The respiratory disease caused by the Coronavirus infectious disease 2019 (COVID19) has spread rapidly since December 2019 in Wuhan, China. This new strain of Coronavirus is similar to the SARS Corona virus and has been termed SARS-CoV-2. Both viruses have emerged from bats and adapted to humans. On March 11, 2020 COVID19 was declared Pandemic by the WHO and as of May 1, 2020 COVID19 disease continues to grow rapidly with 3,400,595 cases and 239,583 deaths world-wide. This review describes the biology of SARSCOV2, Detection, Macrophage-Mediated Pathogenesis and Potential Treatments.

摘要

由2019年冠状病毒病（COVID-19）引起的呼吸道疾病自2019年12月起在中国武汉迅速传播。这种新型冠状病毒与严重急性呼吸综合征冠状病毒相似，被命名为SARS-CoV-2。两种病毒均起源于蝙蝠并适应了人类。2020年3月11日，世界卫生组织宣布COVID-19为大流行病，截至2020年5月1日，COVID-19疾病仍在迅速蔓延，全球有3400595例病例，239583人死亡。本综述描述了SARS-CoV-2的生物学特性、检测方法、巨噬细胞介导的发病机制及潜在治疗方法。