用于按需烧伤伤口敷料的胶凝和可溶解水凝胶。
gelling and dissolvable hydrogels for use as on-demand wound dressings for burns.
机构信息
Departments of Chemistry, Biomedical Engineering, and Medicine, Boston University, Boston, MA 02215, USA.
Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
出版信息
Biomater Sci. 2021 Oct 12;9(20):6842-6850. doi: 10.1039/d1bm00711d.
Abstract
Currently, no dressings utilized in burn clinics provide adhesion, hydration or mechanical strength on the same order as human skin as well as the ability to be atraumatically removed. We report the synthesis, characterization, and evaluation of polymerized and subsequent dissolvable hydrogels as burn wound dressings. Hydrogel dressings, from a small library of synthesized materials form , exhibit storage moduli between 100-40 000 Pa, dissolve on-demand within 10 minutes to 90 minutes, swell up to 350%, and adhere to both burned and healthy human skin at 0.2-0.3 N cm. Further, results from an porcine second degree burn model demonstrate functional performance with healing equivalent to conventional treatments with the added benefit of facile, application and subsequent removal dissolution.
摘要
目前，烧伤诊所使用的敷料在提供附着力、保湿性或机械强度方面都无法与人体皮肤相媲美，也无法做到无创伤去除。我们报告了聚合和随后可溶解水凝胶作为烧伤创面敷料的合成、表征和评估。水凝胶敷料由一小部分合成材料组成，其存储模量在 100-40000Pa 之间，在 10 分钟到 90 分钟内按需溶解，溶胀率高达 350%，能够在 0.2-0.3Ncm 的条件下附着在烧伤和健康的人体皮肤上。此外，猪二度烧伤模型的结果表明，其具有与传统治疗方法相当的功能性能，并且具有易于应用和随后去除溶解的额外优势。
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