Centre for Reproductive Health, Clayton, Victoria 3168, Australia.
Department of Molecular and Translational Science, Clayton, Victoria 3168, Australia.
Development. 2021 Sep 1;148(17). doi: 10.1242/dev.199577. Epub 2021 Sep 6.
Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.
在成人组织中，人类子宫内膜具有独特的周期性脱落、无痕修复和再生能力，这发生在女性的生殖生命期间。因此，它为研究这些过程提供了一个杰出的模型。本综述检查了月经和分娩后子宫内膜修复和再生的已知情况，包括与伤口修复的比较以及月经液成分的影响。我们还讨论了子宫内膜干细胞/祖细胞对子宫内膜再生的贡献，包括干细胞生态位和干细胞衍生的细胞外囊泡的重要性。最后，我们评论了子宫内膜上皮类器官在扩展我们对子宫内膜发育和再生以及治疗应用的理解方面的价值。
