State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anethesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Front Endocrinol (Lausanne). 2021 Aug 20;12:712217. doi: 10.3389/fendo.2021.712217. eCollection 2021.
Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets.
异常基因表达和分泌蛋白水平伴随着广泛的病理变化。分泌卷曲相关蛋白（SFRP）家族成员是 Wnt 信号通路的拮抗抑制剂，最近发现它们参与了多种代谢疾病的发病机制，这引起了人们对 SFRP 的广泛关注。先前的报告强调了 SFRP 在脂质代谢、肥胖、2 型糖尿病和心血管疾病中的重要性。在这篇综述中，我们详细介绍了 SFRP，包括它们的结构特征、受体、抑制剂、信号通路和代谢疾病的影响。除了总结与 SFRP 相关的病理学和潜在分子机制外，本综述还进一步提出了将 SFRP 作为疾病生物标志物和治疗靶点的潜在未来用途。
