Beard A R, Drew M G, Hilgard P, Hudson B D, Mann J, Neidle S, Wong L F
Department of Chemistry, University of Reading, Whiteknights, UK.
Anticancer Drug Des. 1987 Dec;2(3):247-52.
The conformations of four 2-substituted-4-deoxy-analogues of podophyllotoxin have been studied using data obtained from X-ray structure determinations and molecular modelling studies. In these, root mean square differences between these structures and those of the cytotoxic agents 6'-bromopodophyllotoxin and colchicine were determined. Attempts have been made to correlate structure with the available biological activity data.
利用X射线结构测定和分子建模研究获得的数据，对鬼臼毒素的四种2-取代-4-脱氧类似物的构象进行了研究。在这些研究中，测定了这些结构与细胞毒性剂6'-溴鬼臼毒素和秋水仙碱的结构之间的均方根差异。已尝试将结构与现有的生物活性数据相关联。
