Behavioral Sciences Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Neuroimaging Genetic Laboratory, Arvin Gene Company, Tehran, Iran.
PLoS One. 2021 Sep 7;16(9):e0256285. doi: 10.1371/journal.pone.0256285. eCollection 2021.
Genetic bases of psychological stress resilience have been studied previously, but mechanisms and genetic variants which are involved in stress resilience are still unclear. The present study aimed to evaluate the associations between variants in dopaminergic pathway genes with stress resilience. Subjects of the present study were divided into four groups. Group A included persons with normal reactions to major life events stressors; group B included persons with an acute stress reaction to major life events stressor; group C included persons with normal reactions to Crises/catastrophes stressors, and group D included persons with an acute stress reaction to Crises/catastrophes stressors. DNA was extracted from the subject's blood, and the entire length of 14 genes DRD1, DRD2, DRD3, DRD4, DRD5, COMT, DBH, TH, MAOA, DDC, DAT, 5-HTT, BDNF, and GDNF were sequenced by automated sequencers ABI 3700. Results showed 24 point mutations in 12 genes, including 16 SNPs and six novel mutations, which were significantly correlated to low-stress resilience. Most of the SNPs were known as risk alleles in psychiatric disorders. Several associations were found between genetic variants and psychological characteristics. Findings suggest dopaminergic as an important pathway in stress and stress resilience also indicated shared genetic bases between low-stress resilience and several psychiatric disorders.
先前已有研究探讨心理压力适应力的遗传基础，但涉及压力适应力的机制和遗传变异仍不清楚。本研究旨在评估多巴胺能通路基因变异与压力适应力之间的关联。本研究的受试者分为四组。A 组包括对重大生活事件应激源反应正常的人；B 组包括对重大生活事件应激源急性应激反应的人；C 组包括对危机/灾难应激源反应正常的人；D 组包括对危机/灾难应激源急性应激反应的人。从受试者的血液中提取 DNA，使用自动测序仪 ABI 3700 对 14 个基因（DRD1、DRD2、DRD3、DRD4、DRD5、COMT、DBH、TH、MAOA、DDC、DAT、5-HTT、BDNF 和 GDNF）的全长进行测序。结果显示 12 个基因中有 24 个点突变，包括 16 个 SNP 和 6 个新突变，这些突变与低应激适应力显著相关。大多数 SNP 被认为是精神障碍的风险等位基因。遗传变异与心理特征之间存在多种关联。研究结果表明多巴胺能作为压力和压力适应力的重要途径，也表明低应激适应力与几种精神障碍之间存在共同的遗传基础。
