Chaleshtori Sirous Sadeghian, Pirkani Zanyar, Fakhr Massoumeh Jabbari, Mokhber Mona
Department of Internal Medicine, Faculty of Veterinary Medicine University of Tehran Tehran Iran.
Institute of Biomedical Research University of Tehran Tehran Iran.
Health Sci Rep. 2025 Jun 11;8(6):e70853. doi: 10.1002/hsr2.70853. eCollection 2025 Jun.
Pulmonary disorders significantly impact worldwide healthcare, highlighting the necessity for enhanced diagnostic and treatment approaches. This narrative review seeks to investigate the potential of extracellular vesicles (EVs) as an innovative therapeutic strategy for diverse pulmonary disorders.
This review synthesizes existing data about the function of extracellular vesicles (EVs) in pulmonary health and pathology, emphasizing their modes of action, including the transfer of proteins, nucleic acids, and lipids for intercellular communication. It also examines the implications of EVs in targeted medication delivery, immunomodulation, and tissue regeneration.
EVs, including microvesicles and exosomes, have demonstrated promise in treating respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis, and acute respiratory distress syndrome (ARDS). Additionally, EVs may serve as valuable biomarkers for early disease detection, prognosis, and monitoring. However, challenges remain regarding the standardization of EV isolation methods and characterization protocols to ensure safety and clinical applicability.
In summary, extracellular vesicles hold potential for transforming the management of pulmonary diseases by providing insights into pathophysiology, enabling early diagnosis, and facilitating personalized treatment approaches. Further exploration of EV-based therapies is necessary to fully realize their potential in improving outcomes for lung disorders.
肺部疾病对全球医疗保健产生重大影响，凸显了加强诊断和治疗方法的必要性。本叙述性综述旨在探讨细胞外囊泡（EVs）作为多种肺部疾病创新治疗策略的潜力。
本综述综合了关于细胞外囊泡（EVs）在肺部健康和病理中的功能的现有数据，强调其作用方式，包括蛋白质、核酸和脂质的转移以进行细胞间通讯。它还研究了EVs在靶向药物递送、免疫调节和组织再生中的意义。
包括微泡和外泌体在内的EVs在治疗慢性阻塞性肺疾病（COPD）、哮喘、肺纤维化和急性呼吸窘迫综合征（ARDS）等呼吸系统疾病方面已显示出前景。此外，EVs可作为疾病早期检测、预后和监测的有价值生物标志物。然而，在确保安全性和临床适用性的EV分离方法和表征方案的标准化方面仍存在挑战。
总之，细胞外囊泡通过深入了解病理生理学、实现早期诊断和促进个性化治疗方法，在改变肺部疾病管理方面具有潜力。有必要进一步探索基于EV的疗法，以充分实现其在改善肺部疾病预后方面的潜力。
