Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Front Cell Infect Microbiol. 2022 Apr 7;12:853840. doi: 10.3389/fcimb.2022.853840. eCollection 2022.
Sepsis refers to a complex syndrome associated with physiological, pathological, and biochemical abnormalities resulted from infection. Sepsis is the major cause of acute respiratory distress syndrome (ARDS). Extracellular vesicles (EVs) are serving as new messengers to mediate cell-cell communication . Non-coding RNAs, proteins and metabolites encapsulated by EVs could result in either pro-inflammatory or anti-inflammatory effects in the recipient cells. Pathogens or host cells derived EVs play an important role in pathogens infection during the occurrence and development of sepsis and ARDS. Additionally, we summarize the potential application for EVs in diagnosis, prevention and treatment for sepsis and ARDS.
脓毒症是一种与感染引起的生理、病理和生化异常相关的复杂综合征。脓毒症是急性呼吸窘迫综合征（ARDS）的主要病因。细胞外囊泡（EVs）作为新的信使，介导细胞间通讯。EVs 包裹的非编码 RNA、蛋白质和代谢物可在受体细胞中产生促炎或抗炎作用。病原体或宿主细胞衍生的 EVs 在脓毒症和 ARDS 的发生和发展过程中病原体感染中发挥重要作用。此外，我们总结了 EVs 在脓毒症和 ARDS 的诊断、预防和治疗中的潜在应用。
