Scott D G, Bacon P A, Bothamley J E, Allen C, Elson C J, Wallington T B
J Rheumatol. 1981 May-Jun;8(3):433-9.
Plasma exchange (PE) was used to treat 9 patients with rheumatoid vasculitis. The immediate development of new lesions was arrested in 7 patients. Two patients continued to develop new lesions. One responded to additional cyclophosphamide plus methyl prednisolone but the other died within days from severe systemic vasculitis. Prolonged PE alone, or PE followed by cyclophosphamide plus methyl prednisolone was associated with healing of existing lesions without relapse. Short term PE, alone or followed by azathioprine, failed to heal existing lesions and relapses occurred within 3 months. IgG rheumatoid factor and anticomplementary activity fell with PE and correlated best with clinical response.
采用血浆置换（PE）治疗9例类风湿性血管炎患者。7例患者新病变的即时发展得到控制。2例患者继续出现新病变。1例对追加环磷酰胺加甲基泼尼松龙有反应，但另1例在数天内死于严重的系统性血管炎。单独延长血浆置换或血浆置换后联合环磷酰胺加甲基泼尼松龙与现有病变愈合且无复发相关。短期单独血浆置换或血浆置换后联合硫唑嘌呤未能使现有病变愈合，且在3个月内复发。IgG类风湿因子和抗补体活性随血浆置换下降，且与临床反应相关性最佳。
