仿生聚-DL-丝氨酸材料能抵抗异物反应。
Bio-inspired poly-DL-serine materials resist the foreign-body response.
机构信息
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.
出版信息
Nat Commun. 2021 Sep 7;12(1):5327. doi: 10.1038/s41467-021-25581-9.
Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.
植入物引起的异物反应（FBR）是一个常见的问题，可能导致植入物失败。低免疫原性丝胶中的高 L-丝氨酸含量和神经递质中的高 D-丝氨酸含量启发我们制备聚-DL-丝氨酸（PSer）材料以减轻 FBR。在这里，我们报告了高度水溶性、生物相容性和易于获得的 PSer 水凝胶，在植入小鼠皮下 1 周和 2 周后仅引起轻微的炎症反应。在植入后 4 周、3 个月和 7 个月时，PSer 水凝胶周围没有明显的胶原囊。炎症细胞因子的组织学分析和 RNA-seq 分析均表明，PSer 水凝胶表现出低的 FBR，与 Mock 组相当。PSer 水凝胶在所有时间点的抗 FBR 性能均优于广泛用作生物惰性材料的聚乙二醇水凝胶，这意味着 PSer 材料在可植入生物材料和生物医学设备中有很大的应用潜力。
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