Dong Dianyu, Tsao Caroline, Hung Hsiang-Chieh, Yao Fanglian, Tang Chenjue, Niu Liqian, Ma Jinrong, MacArthur Joel, Sinclair Andrew, Wu Kan, Jain Priyesh, Hansen Mitchell Ryan, Ly Dorathy, Tang Sebastian Gia-Huy, Luu Tammy My, Jain Parul, Jiang Shaoyi
Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA.
School of Chemical Engineering and Technology, and Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300350, China.
Sci Adv. 2021 Jan 1;7(1). doi: 10.1126/sciadv.abc5442. Print 2021 Jan.
The high mechanical strength and long-term resistance to the fibrous capsule formation are two major challenges for implantable materials. Unfortunately, these two distinct properties do not come together and instead compromise each other. Here, we report a unique class of materials by integrating two weak zwitterionic hydrogels into an elastomer-like high-strength pure zwitterionic hydrogel via a "swelling" and "locking" mechanism. These zwitterionic-elastomeric-networked (ZEN) hydrogels are further shown to efficaciously resist the fibrous capsule formation upon implantation in mice for up to 1 year. Such materials with both high mechanical properties and long-term fibrous capsule resistance have never been achieved before. This work not only demonstrates a class of durable and fibrous capsule-resistant materials but also provides design principles for zwitterionic elastomeric hydrogels.
高机械强度和对纤维囊形成的长期抗性是可植入材料面临的两大挑战。不幸的是，这两种截然不同的特性并未同时具备，反而相互制约。在此，我们报告了一类独特的材料，通过“溶胀”和“锁定”机制将两种弱两性离子水凝胶整合到类似弹性体的高强度纯两性离子水凝胶中。这些两性离子 - 弹性体 - 网络（ZEN）水凝胶进一步表明，在植入小鼠体内长达1年的时间里能有效抵抗纤维囊的形成。此前从未实现过兼具高机械性能和长期抗纤维囊性能的此类材料。这项工作不仅展示了一类耐用且抗纤维囊的材料，还为两性离子弹性体水凝胶提供了设计原则。
