儿童与新冠病毒：为何年轻的免疫系统仍具优势。 - Suppr

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Kids and COVID: why young immune systems are still on top.

作者信息

Mallapaty Smriti

出版信息

Nature. 2021 Sep;597(7875):166-168. doi: 10.1038/d41586-021-02423-8.

DOI:10.1038/d41586-021-02423-8

PMID:34493845

Abstract

摘要

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本文引用的文献

Autoantibodies neutralizing type I IFNs are present in 4% of uninfected individuals over 70 years old and account for 20% of COVID-19 deaths.在 70 岁以上未感染的人群中，有 4%存在中和 I 型干扰素的自身抗体，占 COVID-19 死亡人数的 20%。

Sci Immunol. 2021 Aug 19;6(62). doi: 10.1126/sciimmunol.abl4340.

Risk of infection and transmission of SARS-CoV-2 among children and adolescents in households, communities and educational settings: A systematic review and meta-analysis.家庭、社区和教育环境中儿童和青少年感染和传播 SARS-CoV-2 的风险：系统评价和荟萃分析。

J Glob Health. 2021 Jul 17;11:05013. doi: 10.7189/jogh.11.05013. eCollection 2021.

SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection.SARS-CoV-2 特异性 T 细胞应答在儿童中较低，并随着年龄和感染后时间的增加而增加。

Nat Commun. 2021 Jul 29;12(1):4678. doi: 10.1038/s41467-021-24938-4.

Systems serology detects functionally distinct coronavirus antibody features in children and elderly.系统血清学在儿童和老年人中检测到功能不同的冠状病毒抗体特征。

Nat Commun. 2021 Apr 1;12(1):2037. doi: 10.1038/s41467-021-22236-7.

Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children.儿童 SARS-CoV-2 感染急性期和恢复期的固有细胞特征。

Nat Commun. 2021 Feb 17;12(1):1084. doi: 10.1038/s41467-021-21414-x.

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