Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.
Institute for Sustainable Futures, University of Technology Sydney, Ultimo, Australia.
J Altern Complement Med. 2021 Dec;27(12):1136-1146. doi: 10.1089/acm.2021.0202. Epub 2021 Sep 7.
The integrity and function of the gastrointestinal system is important in disease prevention and management. This study aims to describe the management methods used by Australian adults with suspected increased intestinal permeability (IP) and the association with subjective wellbeing (SWB) and health-related quality of life (HRQoL). Cross-sectional survey of Australian adults diagnosed with IP or have suspected (undiagnosed) IP. Questionnaire items investigating demographic characteristics, self-reported outcome of IP and treatment methods used to manage IP. Participants' HRQoL and SWB according to the 20-Item Short Form Health Survey (SF-20) and Personal Wellbeing Index-Adult (PWI-A) scale, respectively. Participants ( = 589) frequently used dietary products (87.9%), dietary supplements (72.9%) and lifestyle therapies (54.6%) for managing IP. Participants had lower (i.e., worse) mean SWB scores for all domains compared to the Australian population ( < 0.001). The number of days IP reported to affect daily living was negatively correlated with SWB and HRQoL ( < 0.001). Participants that reported an improvement in their IP in the previous 12 months were more likely to be treated by a healthcare practitioner (OR = 2.04, = 0.015), use dietary supplements (OR = 2.66, = 0.003), participate in vigorous exercise (OR = 2.99, < 0.001) and employ vagus nerve stimulation (OR = 3.10, = 0.010). Conversely, they were less likely to consume gluten (OR = 0.35, < 0.001) or use nonsteroidal anti-inflammatory drugs (OR = 0.35, = 0.022). Self-reported improvement of IP (β = 10.70, < 0.001) and use of dietary products (β = 12.12, = 0.008) were predictors of a higher level of SWB. Altered IP may pose a greater health burden than previously thought, with poor SWB and HRQoL reported in Australian adults with self-reported IP. Our results highlight the potential clinical relevance and consequence of altered IP, providing the first indication of a possible relationship between altered IP and both SWB and HRQoL.
胃肠道系统的完整性和功能对于疾病的预防和管理至关重要。本研究旨在描述澳大利亚成年人疑似肠道通透性增加（IP）的管理方法，以及这些方法与主观幸福感（SWB）和健康相关生活质量（HRQoL）之间的关系。
这是一项针对澳大利亚成年人的横断面调查，这些成年人被诊断为 IP 或疑似（未确诊）IP。调查问卷项目调查人口统计学特征、自我报告的 IP 结果以及用于管理 IP 的治疗方法。根据 20 项简明健康调查问卷（SF-20）和个人幸福感指数-成人（PWI-A）量表，分别评估参与者的 HRQoL 和 SWB。
研究结果显示，参与者经常使用饮食产品（87.9%）、膳食补充剂（72.9%）和生活方式疗法（54.6%）来管理 IP。与澳大利亚人群相比，参与者的所有 SWB 领域的平均得分均较低（即更差）（ < 0.001）。报告 IP 影响日常生活的天数与 SWB 和 HRQoL 呈负相关（ < 0.001）。在过去 12 个月内报告 IP 有所改善的参与者更有可能接受医疗保健从业者的治疗（OR = 2.04， = 0.015），使用膳食补充剂（OR = 2.66， = 0.003），进行剧烈运动（OR = 2.99， < 0.001）和采用迷走神经刺激（OR = 3.10， = 0.010）。相反，他们更不可能摄入麸质（OR = 0.35， < 0.001）或使用非甾体抗炎药（OR = 0.35， = 0.022）。IP 自我报告的改善（β = 10.70， < 0.001）和饮食产品的使用（β = 12.12， = 0.008）是 SWB 更高水平的预测因素。
改变的 IP 可能比以前认为的对健康造成更大的负担，报告的澳大利亚成年人的 SWB 和 HRQoL 较差。我们的研究结果突出了改变的 IP 的潜在临床相关性和后果，首次表明改变的 IP 与 SWB 和 HRQoL 之间可能存在关系。
