Post-Graduation Program in Pharmaceutical Sciences, State University of Maringá, Maringá, Brazil.
Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo, Brazil and Immunobiological Production Section, Bioindustrial Center, Butantan Institute, São Paulo, Brazil.
J Med Food. 2022 Jan;25(1):110-113. doi: 10.1089/jmf.2021.0026. Epub 2021 Sep 7.
We previously reported that a high-carbohydrate diet (HCD) induced systemic inflammation and higher gene expression of proinflammatory mediators in the liver, skeletal muscle, and brain than a high-fat diet (HFD). However, the differences between the groups were less pronounced in the brain. In this study, we extended the evaluation of inflammation to specific areas of the brain. In this study, we evaluated the gene expression of , cyclooxygenase-2 (), inducible nitric oxide synthase (), interleukin (IL), , tumor necrosis factor-alpha (), integrin subunit alpha m (), S100 protein (), allograft inflammatory factor 1 (), and glial fibrillary acidic protein () in the prefrontal cortex and hippocampus of male Swiss mice that were fed with HCD or HFD for 8 weeks. The HCD group exhibited higher expression, whereas the HFD group showed higher expression in the prefrontal cortex. In the hippocampus, expression was higher in the HFD group. IL-1 and TNF- are proinflammatory cytokines that have been associated with impaired brain function and numerous brain disorders. Our results indicate that both HCD and HFD promote prefrontal cortex inflammation; however, the hippocampus seems more sensitive to a HFD than HCD.
我们之前曾报道，与高脂肪饮食（HFD）相比，高碳水化合物饮食（HCD）会引起全身炎症和肝脏、骨骼肌和大脑中促炎介质的基因表达升高。然而，两组在大脑中的差异并不明显。在这项研究中，我们将炎症评估扩展到大脑的特定区域。在这项研究中，我们评估了雄性瑞士小鼠的前额叶皮层和海马体中环氧合酶-2 ()、诱导型一氧化氮合酶 ()、白细胞介素 ()、肿瘤坏死因子-α ()、整合素亚基α m ()、S100 蛋白 ()、同种异体炎症因子 1 () 和神经胶质纤维酸性蛋白 () 的基因表达，这些小鼠分别用 HCD 或 HFD 喂养 8 周。HCD 组表现出更高的 表达，而 HFD 组则在前额叶皮层表现出更高的 表达。在海马体中，HFD 组的 表达更高。IL-1 和 TNF-是与脑功能障碍和许多脑部疾病相关的促炎细胞因子。我们的结果表明，HCD 和 HFD 均会促进前额叶皮层炎症；然而，与 HCD 相比，HFD 似乎对海马体更为敏感。
