Wójcicki J, Samochowiec L, Dadej R, Jaworska M, Gawrońska-Szklarz B, Kownacka A, Ryshenkov V, Chistyakova A, Acsenova N
Institute of Pharmacology and Toxicology, Medical Academy, Szczecin, Poland.
Pol J Pharmacol Pharm. 1987 Jul-Aug;39(4):343-51.
To assess the hypolipemic and antiatherosclerotic activity of diprophyllinyl-4-benzyloxybenzoate guinea-pigs were kept on a high-lipid diet alone or with the tested compound for 21 days, and rabbits--for 3 months. It was found that diprophyllinyl-4-benzyloxybenzoate displays a distinct hypolipemic activity, particularly with respect to cholesterol, both in guinea-pigs and rabbits. It also depresses the cholesterol and the trigliceride content in liver homogenates and shows a tendency to normalize the low-density-lipoprotein fraction in guinea-pigs, as well as cholesterol of the high-density lipoprotein fraction, and malon dialdehyde in rabbits. The area of intima covered with atheromatous plaques was smaller in rabbits receiving the high-lipid diet with diprophyllinyl-4-benzyloxybenzoate than in those receiving that diet alone.
为评估4-苄氧基苯甲酸二丙茶碱酯的降血脂和抗动脉粥样硬化活性，将豚鼠单独喂以高脂饮食或与受试化合物一起喂饲21天，将兔子喂饲3个月。结果发现，4-苄氧基苯甲酸二丙茶碱酯在豚鼠和兔子中均表现出明显的降血脂活性，尤其是对胆固醇。它还能降低肝匀浆中的胆固醇和甘油三酯含量，并使豚鼠的低密度脂蛋白部分、兔子的高密度脂蛋白部分胆固醇以及丙二醛趋于正常化。接受高脂饮食加4-苄氧基苯甲酸二丙茶碱酯的兔子，其覆盖动脉粥样斑块的内膜面积比单独接受高脂饮食的兔子小。
