Arthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Arthritis Institute, Peking University, Beijing, China.
Cell Prolif. 2021 Oct;54(10):e13113. doi: 10.1111/cpr.13113. Epub 2021 Sep 8.
In recent years, long non-coding RNAs (lncRNAs) have been found to play a role in the occurrence, progression and prognosis of chronic musculoskeletal disorders.
Literature exploring on PubMed was conducted using the combination of keywords 'LncRNA' and each of the following: 'osteoarthritis', 'rheumatoid arthritis', 'osteoporosis', 'osteogenesis', 'osteoclastogenesis', 'gout arthritis', 'Kashin-Beck disease', 'ankylosing spondylitis', 'cervical spondylotic myelopathy', 'intervertebral disc degeneration', 'human muscle disease' and 'muscle hypertrophy and atrophy'. For each disorder, we focused on the publications in the last five years (5/1/2016-2021/5/1, except for Kashin-Beck disease). Finally, we excluded publications that had been reported in reviews of various musculoskeletal disorders during the last three years. Here, we summarized the progress of research on the role of lncRNA in multiple pathological processes during musculoskeletal disorders.
LncRNAs play a crucial role in regulating downstream gene expression and maintaining function and homeostasis of cells, especially in chondrocytes, synovial cells, osteoblasts, osteoclasts and skeletal muscle cells.
Understanding the mechanisms of lncRNAs in musculoskeletal disorders may provide promising strategies for clinical practice.
近年来，长链非编码 RNA（lncRNA）被发现参与慢性肌肉骨骼疾病的发生、发展和预后。
使用关键词“LncRNA”与以下每个词的组合，在 PubMed 上进行文献探索：“骨关节炎”、“类风湿关节炎”、“骨质疏松症”、“成骨”、“破骨细胞生成”、“痛风性关节炎”、“大骨节病”、“强直性脊柱炎”、“颈椎病脊髓病”、“椎间盘退变”、“人类肌肉疾病”和“肌肉肥大和萎缩”。对于每种疾病，我们重点关注过去五年（2016 年 5 月 1 日至 2021 年 5 月 1 日，除大骨节病外）的出版物。最后，我们排除了过去三年在各种肌肉骨骼疾病综述中报道过的出版物。在这里，我们总结了 lncRNA 在肌肉骨骼疾病多种病理过程中作用的研究进展。
lncRNA 在调节下游基因表达和维持细胞功能和内稳态方面发挥着关键作用，尤其是在软骨细胞、滑膜细胞、成骨细胞、破骨细胞和骨骼肌细胞中。
了解 lncRNA 在肌肉骨骼疾病中的作用机制可能为临床实践提供有前途的策略。
