接种 BNT162b2 疫苗后不久感染 SARS-CoV-2 可使疗养院居民和工作人员的抗刺突抗体水平升高。
SARS-CoV-2 infection shortly after BNT162b2 vaccination results in high anti-spike antibody levels in nursing home residents and staff.
机构信息
Department for Immunology, Leibniz Research Centre for Working Environment and Human Factors (IfADo) at TU Dortmund, Dortmund, Germany.
Dortmund Health Department, Dortmund, Germany.
出版信息
Immun Inflamm Dis. 2021 Dec;9(4):1702-1706. doi: 10.1002/iid3.525. Epub 2021 Sep 9.
INTRODUCTION
One dose of a coronavirus disease 2019 (COVID-19) vaccine can elicit high antibody titers in individuals who were previously infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, it is unclear how a SARS-CoV-2 infection shortly after a first COVID-19 vaccine dose affects antibody responses.
METHODS
Here we investigate residents and staff of a nursing home, where a COVID-19 outbreak occurred shortly after the first BNT162b2 immunization.
RESULTS AND CONCLUSIONS
Our data show that individuals who got infected as early as 10 days after their first immunization show antibody levels comparable to fully vaccinated individuals.
简介
新型冠状病毒病（COVID-19）疫苗一剂可在先前感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的个体中引发高抗体滴度。然而，尚不清楚 SARS-CoV-2 感染在第一剂 COVID-19 疫苗后不久如何影响抗体反应。
方法
在这里，我们调查了一家疗养院的居民和工作人员，该疗养院在第一剂 BNT162b2 免疫接种后不久发生了 COVID-19 爆发。
结果与结论
我们的数据表明，最早在首次免疫后 10 天就感染的个体显示出与完全接种疫苗的个体相当的抗体水平。
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