Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Xiangya Hospital of Central South University, Changsha 410008, China.
Molecules. 2021 Sep 5;26(17):5401. doi: 10.3390/molecules26175401.
Four new biflavonoids (-) were isolated from together with a known biflavonoid derivative (). Their structures contained a rare linker of individual flavones to each other by direct C-3-O-C-4''' bonds, and were elucidated by extensive spectroscopic data, including HRESIMS, NMR and ECD data. All isolates significantly inhibited the proliferation of NSCLC cells (IC = 2.3-8.4 μM) with low toxicity to non-cancer MRC-5 cells, superior to the clinically used drug DDP. Furthermore, the most active compound suppressed XIAP and survivin expression, promoted upregulation of caspase-3/cleaved-caspase-3, as well as induced cell apoptosis and cycle arrest in A549 cells. Together, our findings suggest that may be worth studying further for intervention of NSCLC.
从 中分离得到四个新的二氢黄酮类化合物 (-)，以及一个已知的二氢黄酮类衍生物 ()。它们的结构包含通过直接 C-3-O-C-4'''键将单体黄酮彼此连接的罕见连接子，并通过广泛的光谱数据，包括 HRESIMS、NMR 和 ECD 数据进行阐明。所有分离物均显著抑制 NSCLC 细胞的增殖（IC = 2.3-8.4 μM），对非癌细胞 MRC-5 的毒性较低，优于临床使用的药物顺铂。此外，最活跃的化合物 抑制 XIAP 和 survivin 的表达，促进 caspase-3/cleaved-caspase-3 的上调，并诱导 A549 细胞凋亡和周期停滞。总之，我们的研究结果表明， 可能值得进一步研究以干预 NSCLC。
