Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China and National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), South China University of Technology, Guangzhou, 510641, People's Republic of China and Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, P. R. China.
Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China and National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), South China University of Technology, Guangzhou, 510641, People's Republic of China and Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510641, China.
Biomater Sci. 2020 May 6;8(9):2694-2701. doi: 10.1039/d0bm00322k.
A multifunctional and effective medical adhesive with a combination of high toughness and superior adhesion is highly desired in biomedical fields. However, clinical application of medical adhesives is still limited due to their weak adhesion to wet tissue. In this study, a novel medical adhesive called TASK composed of tannic acid (TA) and silk fibroin (SF) based on polyphenol-gel systems was developed. TASK powder was prepared by a simple physical mixture of pyrogallol-rich tannic acid and silk fibroin in aqueous solution and further freeze drying, which was stable and convenient for sterilization before clinical application. The TASK composite gel was formed by just adding water to the TASK powder. TASK showed improved wet-adhesive properties and stability; its adhesion strength after 5 h in water reached 180.9 ± 27.4 kPa. ATR-FTIR results indicated that the plentiful phenolic hydroxyl groups in TA allowed TASK to maintain adhesion to tissue in a wet environment. Furthermore, no chemical modification or covalent cross-linking was required for this wet-adhesive TASK which may facilitate its clinical application.
在生物医学领域，人们非常希望有一种多功能、高效的医用胶粘剂，它具有高韧性和优异的粘附性。然而，由于其对湿组织的粘附力较弱，医用胶粘剂的临床应用仍然受到限制。在这项研究中，开发了一种名为 TASK 的新型医用胶粘剂，它由基于多酚凝胶体系的单宁酸（TA）和丝素蛋白（SF）组成。TASK 粉末通过富邻苯三酚单宁酸和丝素蛋白在水溶液中的简单物理混合物以及进一步的冷冻干燥来制备，在临床应用前稳定且便于消毒。只需向 TASK 粉末中加水即可形成 TASK 复合凝胶。TASK 表现出改善的湿粘附性能和稳定性；其在水中 5 小时后的粘附强度达到 180.9 ± 27.4 kPa。ATR-FTIR 结果表明，TA 中丰富的酚羟基基团使 TASK 能够在潮湿环境中保持对组织的粘附。此外，这种湿粘附 TASK 不需要化学修饰或共价交联，这可能有助于其临床应用。
