Programa de Oncovirologia, Instituto Nacional de Câncer, Rio de Janeiro 20231-050, RJ, Brazil.
Int J Mol Sci. 2019 Dec 28;21(1):222. doi: 10.3390/ijms21010222.
The microbiome is able to modulate immune responses, alter the physiology of the human organism, and increase the risk of viral infections and development of diseases such as cancer. In this review, we address changes in the cervical microbiota as potential biomarkers to identify the risk of cervical intraepithelial neoplasia (CIN) development and invasive cervical cancer in the context of human papillomavirus (HPV) infection. Current approaches for clinical diagnostics and the manipulation of microbiota with the use of probiotics and through microbiota transplantation are also discussed.
微生物组能够调节免疫反应，改变人体生理机能，并增加病毒感染和癌症等疾病发展的风险。在这篇综述中，我们探讨了宫颈微生物组的变化作为潜在的生物标志物，以识别人乳头瘤病毒（HPV）感染背景下宫颈上皮内瘤变（CIN）发展和浸润性宫颈癌的风险。目前的临床诊断方法以及利用益生菌和通过菌群移植来操纵菌群的方法也进行了讨论。
