基于外泌体的癌症治疗药物递送的最新进展

Kim Hyosuk, Jang Hochung, Cho Haeun, Choi Jiwon, Hwang Kwang Yeon, Choi Yeonho, Kim Sun Hwa, Yang Yoosoo

Center for Theragnosis, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.

Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea.

Cancers (Basel). 2021 Sep 2;13(17):4435. doi: 10.3390/cancers13174435.

Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocompatibility and low immunogenicity for efficient delivery of therapeutic agents such as chemotherapeutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of exosome-based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.

外泌体是一类细胞外囊泡，大小约为100纳米，由大多数细胞分泌，携带核酸、蛋白质和脂质等各种生物活性分子，反映母细胞的生物学状态。外泌体具有生物相容性高和免疫原性低等天然优势，可有效递送化疗药物、核酸和蛋白质等治疗剂。在本综述中，我们介绍了基于外泌体的癌症治疗药物递送系统的最新探索，特别关注各种类型货物的靶向递送。