Xu Tingting, Xie Mengyan, Jing Xinming, Cui Jiahua, Wu Xi, Shu Yongqian
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210003, China.
Department of Oncology, Sir Run Run Hospital, Nanjing Medical University, Nanjing 210003, China.
Cancers (Basel). 2021 Sep 2;13(17):4436. doi: 10.3390/cancers13174436.
There is a clear relationship between inflammatory response and different stages of tumor development. Common inflammation-related carcinogens include viruses, bacteria, and environmental mutagens, such as air pollutants, toxic metals, and ultraviolet light. The expression pattern of ncRNA changes in a variety of disease conditions, including inflammation and cancer. Non-coding RNAs (ncRNAs) have a causative role in enhancing inflammatory stimulation and evading immune responses, which are particularly important in persistent pathogen infection and inflammation-to-cancer transformation. In this review, we investigated the mechanism of ncRNA expression imbalance in inflammation-related cancers. A better understanding of the function of inflammation-associated ncRNAs may help to reveal the potential of ncRNAs as a new therapeutic strategy.
炎症反应与肿瘤发展的不同阶段之间存在明确的关系。常见的炎症相关致癌物包括病毒、细菌和环境诱变剂，如空气污染物、有毒金属和紫外线。ncRNA的表达模式在包括炎症和癌症在内的多种疾病状态下会发生变化。非编码RNA（ncRNAs）在增强炎症刺激和逃避免疫反应中具有因果作用，这在持续性病原体感染和炎症向癌症的转变中尤为重要。在本综述中，我们研究了炎症相关癌症中ncRNA表达失衡的机制。更好地理解炎症相关ncRNAs的功能可能有助于揭示ncRNAs作为一种新治疗策略的潜力。
