当前对铁死亡在胰腺癌进展和治疗中的理解。
Current understanding of ferroptosis in the progression and treatment of pancreatic cancer.
作者信息
Dong Shi, Li Xin, Jiang Wenkai, Chen Zhou, Zhou Wence
机构信息
The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Department of General Surgery, Gansu Province, The First Hospital of Lanzhou University, No. 1, Donggang West Road, Chengguan District, Lanzhou City, 730000, China.
出版信息
Cancer Cell Int. 2021 Sep 9;21(1):480. doi: 10.1186/s12935-021-02166-6.
Pancreatic cancer is a highly malignant tumour of the digestive tract. Despite advances in treatment, its 5-year survival rate remains low, and its prognosis is the worst among all cancers; innovative therapeutic methods are needed. Ferroptosis is a form of regulatory cell death driven by iron accumulation and lipid peroxidation. Recent studies have found that ferroptosis plays an important role in the development and treatment response of tumours, particularly pancreatic cancer. This article reviews the current understanding of the mechanism of ferroptosis and ferroptosis-related treatment in pancreatic cancer.
胰腺癌是一种消化道高度恶性肿瘤。尽管治疗取得了进展，但其5年生存率仍然很低，在所有癌症中预后最差；需要创新的治疗方法。铁死亡是一种由铁积累和脂质过氧化驱动的调节性细胞死亡形式。最近的研究发现，铁死亡在肿瘤尤其是胰腺癌的发生发展和治疗反应中起重要作用。本文综述了目前对胰腺癌中铁死亡机制及铁死亡相关治疗的认识。
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