Hofmeyr J H
Dept. of Biochemistry, University of Stellenbosch, South Africa.
Comput Appl Biosci. 1986 Apr;2(1):5-11. doi: 10.1093/bioinformatics/2.1.5.
Steady-state modelling and control analysis by means of computer simulation provides valuable insight into the behavior of metabolic pathways. This review, which is aimed at the newcomer to this field, discusses the objectives of steady-state modelling and the steady-state properties of the four basic metabolic structures, namely linear and branched chains, loops and cycles. It is shown how the model definition in terms of stoichiometric reactions and rate equations leads to a set of balance equations from which the conservation constraints and flux relationships can be deduced, either informally or through a rigorous analysis of the stoichiometric matrix. The initial analysis of a steady-state metabolic model is summarized in an algorithm. Key references to the literature on metabolic modelling are given.
通过计算机模拟进行稳态建模和控制分析，能为代谢途径的行为提供有价值的见解。这篇针对该领域新手的综述，讨论了稳态建模的目标以及四种基本代谢结构（即线性链、分支链、环和循环）的稳态特性。文中展示了如何根据化学计量反应和速率方程来定义模型，从而得出一组平衡方程，通过非正式方式或对化学计量矩阵进行严格分析，从中推导出守恒约束和通量关系。稳态代谢模型的初始分析总结在一个算法中。还给出了代谢建模文献的关键参考文献。
