Sharifi-Rad Javad, Quispe Cristina, Rahavian Amirhossein, Pereira Carneiro Joara Nályda, Rocha Janaína Esmeraldo, Alves Borges Leal Antônio Linkoln, Bezerra Morais Braga Maria Flaviana, Melo Coutinho Henrique Douglas, Ansari Djafari Anahita, Alarcón-Zapata Pedro, Martorell Miquel, Antika Gizem, Tumer Tugba Boyunegmez, Cruz-Martins Natália, Helon Paweł, Paprocka Paulina, Koch Wojciech, Docea Anca Oana, Calina Daniela
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Facultad de Ciencias de La Salud, Universidad Arturo Prat, Iquique, Chile.
Front Pharmacol. 2021 Aug 24;12:674682. doi: 10.3389/fphar.2021.674682. eCollection 2021.
Sexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative review aims to present updated information about the use of natural bioactive compounds for the prevention and treatment of sexually transmitted infections. A search of the literature was performed using databases and search engines such as PubMed, Scopus, Google Scholar and Science Direct. From the pharmacotherapeutic management point of view, any strategies for prevention should contain medical approaches. The bioactive compounds obtained from natural products have shown biological effects against different microorganisms for the treatment of these diseases. The main results showed antimicrobial, antiprotozoal, antifungal and antiviral effects such as HIV. Also, the molecular mechanisms, signalling pathways and action targets of natural compounds were highlighted, thus justifying bacterial and antifungal inhibition, apoptosis or reduction of viral replication. From the data of our study, we can conclude that natural compounds may be a significant source for adjuvant drugs / complementary therapies in the treatment of STDs. With all these benefits, the future must conduct extensive clinical trials and the development of pharmaceutical nanotechnologies for a greater therapeutic effect.
性传播疾病（STDs）由细菌、真菌、寄生虫和病毒等病原体引起，可能会引发严重的健康问题，如癌症、溃疡，甚至新生儿问题。本叙述性综述旨在介绍有关天然生物活性化合物用于预防和治疗性传播感染的最新信息。通过使用PubMed、Scopus、谷歌学术和科学Direct等数据库和搜索引擎对文献进行了检索。从药物治疗管理的角度来看，任何预防策略都应包含医学方法。从天然产物中获得的生物活性化合物已显示出针对不同微生物治疗这些疾病的生物学效应。主要结果显示出抗菌、抗原虫、抗真菌和抗病毒作用，如对HIV的作用。此外，还强调了天然化合物的分子机制、信号通路和作用靶点，从而解释了细菌和真菌抑制、细胞凋亡或病毒复制减少的原因。根据我们的研究数据，我们可以得出结论，天然化合物可能是治疗性传播疾病辅助药物/补充疗法的重要来源。鉴于所有这些益处，未来必须进行广泛的临床试验并开发药物纳米技术以获得更大的治疗效果。
