Department of Biochemistry, Nepalese Army Institute of Health Sciences, Bhandarkhal, Kathmandu, Nepal.
Department of Pathology, Nepalese Army Institute of Health Sciences Bhandarkhal, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2021 Feb 28;59(234):170-175. doi: 10.31729/jnma.6191.
Thyroid dysfunction prevalence is high in females worldwide which increases with age. Postmenopausal and elderly women are particularly at risk of developing comorbidities and mortality related to thyroid dysfunction. We aimed to study the prevalence of thyroid dysfunction in postmenopausal women in the National Reference Laboratory of Nepal.
A descriptive cross-sectional study was conducted in National Reference Laboratory from January 2019 to June 2019 including postmenopausal females, ≥49 years. The database of thyroid function test result was used for statistical analysis and proportion of thyroid dysfunction was calculated. The data was collected after approval from the institutional review committee. Statistical Package for Social Sciences version 21 was used to study descriptive data.
Out of a total of 160 postmenopausal females with thyroid function tests, 71 (44.4%) had thyroid dysfunction. Subclinical hypothyroidism was the frequently occurring thyroid dysfunction 51 (32%) followed by subclinical hyperthyroidism 13 (8%), hypothyroidism 3 (2%) and hyperthyroidism 3 (2%). In our study population, thyroid dysfunction peaked at 49 to 58 years of age interval 53 (33.1%) and subclinical hypothyroidism was the most frequent form 38 (23.7%).
Subclinical hypothyroidism was the common thyroid dysfunction in postmenopausal age which peaked at 49 to 58 years of age group. Early postmenopausal females are predisposed to increased risk of comorbidities (cardiovascular disease, osteoporosis with high fracture, depression) which could be exacerbated with thyroid dysfunction; therefore awareness of thyroid dysfunction prevalence and thyroid screening for early management seems appropriate in Nepalese postmenopausal women.
全球范围内，女性甲状腺功能紊乱的患病率较高，且随年龄增长而增加。绝经后和老年女性尤其有发生与甲状腺功能紊乱相关的合并症和死亡的风险。我们旨在研究尼泊尔国家参考实验室绝经后女性甲状腺功能紊乱的患病率。
这是一项 2019 年 1 月至 6 月在国家参考实验室进行的描述性横断面研究，纳入了年龄≥49 岁的绝经后女性。使用甲状腺功能检测结果数据库进行统计分析，并计算甲状腺功能紊乱的比例。该数据是在获得机构审查委员会批准后收集的。使用社会科学统计软件包（SPSS）版本 21 研究描述性数据。
在总共 160 名接受甲状腺功能检查的绝经后女性中，有 71 名（44.4%）患有甲状腺功能紊乱。亚临床甲状腺功能减退症是最常见的甲状腺功能紊乱，有 51 例（32%），其次是亚临床甲状腺功能亢进症 13 例（8%）、甲状腺功能减退症 3 例（2%）和甲状腺功能亢进症 3 例（2%）。在我们的研究人群中，甲状腺功能紊乱的峰值出现在 49 至 58 岁年龄组，有 53 例（33.1%），其中最常见的形式是亚临床甲状腺功能减退症，有 38 例（23.7%）。
亚临床甲状腺功能减退症是绝经后年龄中常见的甲状腺功能紊乱，其峰值出现在 49 至 58 岁年龄组。早期绝经后女性更容易发生合并症（心血管疾病、骨质疏松症伴高骨折、抑郁症），甲状腺功能紊乱可能会使这些风险加剧；因此，在尼泊尔绝经后女性中，提高对甲状腺功能紊乱患病率的认识并进行甲状腺筛查以进行早期管理似乎是合适的。
