Hua Youwei, He Zhihui, Zhang Xu
School of Mathematics and Statistics, Southwest University, Chongqing, China.
Department of Pediatric Respiration, Chongqing Ninth People's Hospital, Chongqing, China.
Cancer Biomark. 2022;34(1):23-39. doi: 10.3233/CBM-203247.
Emerging evidence has revealed a relationship between lamin B1 (LMNB1) and several cancers such as cervical cancer, liver cancer, and prostate cancer. But no systematic pan-cancer analysis is available. Little is known about the clinical significance and biomarker utility of LMNB1. In this study, we first revealed the key role of LMNB1 in esophageal carcinoma (ESCA) through weighted gene co-expression network analysis (WGCNA) and disease-free survival (DFS) analysis. Based on this result and the datasets of the cancer genome atlas (TCGA), we explored the biomarker utility of LMNB1 across thirty-three tumors. We found that LMNB1 was highly expressed in most of the cancers and significant associations existed between LMNB1 expression and prognosis of cases of nearly half of the cancers. We also found that LMNB1 expression was associated with the infiltration level of Macrophages M1 and T cells CD4 memory activated in some cancers. Moreover, LMNB1 was mainly involved in the functional mechanisms of MRNA binding, olfactory transduction, and gene silencing. Our study first provides a pan-cancer study of LMNB1, thereby offering a relatively comprehensive understanding of the biomarker utility of LMNB1 across thirty-three tumors.
新出现的证据揭示了核纤层蛋白B1（LMNB1）与几种癌症之间的关系，如宫颈癌、肝癌和前列腺癌。但尚无系统性的泛癌分析。关于LMNB1的临床意义和生物标志物效用知之甚少。在本研究中，我们首先通过加权基因共表达网络分析（WGCNA）和无病生存期（DFS）分析揭示了LMNB1在食管癌（ESCA）中的关键作用。基于这一结果以及癌症基因组图谱（TCGA）的数据集，我们探讨了LMNB1在33种肿瘤中的生物标志物效用。我们发现LMNB1在大多数癌症中高表达，并且在近一半癌症病例的LMNB1表达与预后之间存在显著关联。我们还发现LMNB1表达与某些癌症中M1巨噬细胞和CD4记忆激活T细胞的浸润水平相关。此外，LMNB1主要参与mRNA结合、嗅觉转导和基因沉默的功能机制。我们的研究首次提供了对LMNB1的泛癌研究，从而对LMNB1在33种肿瘤中的生物标志物效用提供了相对全面的理解。
