Department of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, China.
Department of Urology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Int J Biol Sci. 2021 Jul 31;17(13):3356-3368. doi: 10.7150/ijbs.61175. eCollection 2021.
Urologic oncologies are major public health problems worldwide. Both microRNA and autophagy, separately or concurrently, are involved in a variety of the cellular and molecular processes of multiple cancers, including urologic malignancies. In this review, we have summarized the related studies and found that microRNA-mediated autophagy acted as carcinogenic factors or suppressors in prostate cancer, kidney cancer, and bladder cancer. MiRNAs, targeted genes, and the different signaling pathways constitute a complex network that orchestrates autophagy regulation, militating the oncogenic and tumor-suppressive effects in urologic malignancies. Aberrant expression of miRNAs may induce the dysregulation of the autophagy process, resulting in tumorigenesis, progression, and resistance to anticancer therapies. Targeting specific miRNAs for autophagy modulation may present as reliable diagnostic and prognostic biomarkers or promising therapeutic strategies for urologic oncologies.
泌尿系统肿瘤是全球主要的公共卫生问题。miRNA 和自噬分别或同时参与多种癌症包括泌尿系统恶性肿瘤的多种细胞和分子过程。在这篇综述中，我们总结了相关研究，发现 miRNA 介导的自噬在前列腺癌、肾癌和膀胱癌中作为致癌因子或抑制因子发挥作用。miRNAs、靶向基因和不同的信号通路构成了一个复杂的网络，协调自噬的调节，在泌尿系统恶性肿瘤中发挥致癌和抑癌作用。miRNAs 的异常表达可能导致自噬过程的失调，从而导致肿瘤发生、进展和对癌症治疗的耐药性。针对自噬调节的特定 miRNAs 可能成为泌尿系统肿瘤可靠的诊断和预后生物标志物或有前途的治疗策略。
