Mariani Nicole
Stress, Psychiatry and Immunology Laboratory, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Brain Behav Immun Health. 2021 Aug 10;16:100323. doi: 10.1016/j.bbih.2021.100323. eCollection 2021 Oct.
It is becoming clearer that it might be a combination of different biological processes such as genetic, environmental, and psychological factors, together with immune system, stress response, brain neuroplasticity and the regulation of neurotransmitters, that leads to the development of major depressive disorder (MDD). A growing number of studies have tried to investigate the underlying mechanisms of MDD by analysing the expression levels of genes (mRNA) involved in such biological processes. In this review, I have highlighted a possible key role that gene expression might play in the treatment of MDD. This is critical because many patients do not respond to antidepressant treatment or can experience side effects, causing treatment to be interrupted. Unfortunately, selecting the best antidepressant for each individual is still largely a matter of making an informed guess.
越来越清楚的是，可能是遗传、环境和心理因素等不同生物过程，连同免疫系统、应激反应、大脑神经可塑性以及神经递质的调节，共同导致了重度抑郁症（MDD）的发生。越来越多的研究试图通过分析参与此类生物过程的基因（mRNA）表达水平来探究MDD的潜在机制。在这篇综述中，我强调了基因表达可能在MDD治疗中发挥的关键作用。这一点至关重要，因为许多患者对抗抑郁治疗无反应或会出现副作用，导致治疗中断。不幸的是，为每个个体选择最佳抗抑郁药在很大程度上仍然只是一种有根据的猜测。
